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Dentaljuce Shorts: 500 words, 10 MCQs, on general medicine and surgery.


Hepatoblastoma is a malignant liver cancer that primarily affects infants and children. It is composed of tissue resembling foetal liver cells, mature liver cells, or bile duct cells. The disease typically presents with an abdominal mass and is most commonly diagnosed during a child's first three years of life. Elevated alpha-fetoprotein (AFP) levels are a common diagnostic marker; however, the prognosis is poorer when AFP levels are not elevated at diagnosis.

Micrograph of a hepatoblastoma. H&E stain.
Micrograph of a hepatoblastoma. H&E stain.


Patients with hepatoblastoma are usually asymptomatic at the time of diagnosis, which often leads to the disease being advanced by the time it is detected. The most noticeable sign is typically an abdominal mass, which is often the first indication that prompts further investigation.

Signs and Symptoms

Hepatoblastomas originate from immature liver precursor cells and are typically unifocal, affecting the right lobe of the liver more frequently than the left. These tumours can metastasize. Hepatoblastomas are categorised into two types: "Epithelial Type" and "Mixed Epithelial / Mesenchymal Type."

Micrograph showing a hepatoblastoma (right of image) and normal liver (left of image). H&E stain.
Micrograph showing a hepatoblastoma (right of image) and normal liver (left of image). H&E stain.

Certain genetic conditions and syndromes are associated with an increased incidence of hepatoblastoma. For instance, individuals with familial adenomatous polyposis (FAP) frequently develop hepatoblastomas. Beta-catenin mutations are common in sporadic hepatoblastomas, occurring in up to 67% of patients. Other syndromes with increased hepatoblastoma incidence include Beckwith–Wiedemann syndrome, trisomy 18, trisomy 21, Acardi syndrome, Li–Fraumeni syndrome, Goldenhar syndrome, von Gierke disease, and familial adenomatous polyposis.

Liver tumour types by relative incidence in adults in the United States, with hepatoblastoma at right
Liver tumour types by relative incidence in adults in the United States, with hepatoblastoma at right.


The primary diagnostic method for hepatoblastoma is a blood test to check AFP levels. AFP serves as a biomarker to determine the presence of liver cancer in children. At birth, infants have high AFP levels, which fall to normal adult levels by the second year of life. Normal AFP levels are considered to be lower than 50 nanograms per millilitre (ng/ml) in children and 10 ng/ml in adults. An AFP level greater than 500 ng/ml is a significant indicator of hepatoblastoma. AFP levels are also monitored to assess treatment efficacy, with expected normalisation of AFP levels if treatments are successful.


Treatment options for hepatoblastoma include surgical removal of the tumour, neoadjuvant chemotherapy prior to surgery, and liver transplantation. Primary liver transplantation offers a high long-term disease-free survival rate of approximately 80%. In cases where complete tumour removal and adjuvant chemotherapy are achieved, survival rates can approach 100%. The presence of metastases is the strongest predictor of poor prognosis.

Self-assessment MCQs (single best answer)

What is hepatoblastoma primarily composed of?

At what age is hepatoblastoma most commonly diagnosed?

Which biomarker is commonly elevated in patients with hepatoblastoma?

What is the most noticeable sign of hepatoblastoma?

Which genetic condition is frequently associated with hepatoblastomas?

Hepatoblastomas are categorised into which two types?

Which of the following is NOT a syndrome associated with increased hepatoblastoma incidence?

What AFP level is considered a significant indicator of hepatoblastoma?

What is the strongest predictor of poor prognosis in hepatoblastoma?

Which treatment option offers a high long-term disease-free survival rate of approximately 80% for hepatoblastoma?


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