Enhanced Verifiable CPD from the
University of Birmingham

Dentaljuce Shorts: 500 words, 10 MCQs, on general medicine and surgery.



Sarcoidosis, also known as Besnier–Boeck–Schaumann disease, is a systemic inflammatory condition characterised by the formation of granulomas—abnormal collections of inflammatory cells. It most commonly affects the lungs, skin, and lymph nodes, though any organ can be involved. The disease's cause is unknown, but genetic predisposition and environmental or infectious triggers are suspected.

Chest X-ray showing the typical nodularity of sarcoidosis, predominantly in the hila of the lungs.
Chest X-ray showing the typical nodularity of sarcoidosis, predominantly in the hila of the lungs.

Signs and Symptoms

Sarcoidosis symptoms vary depending on the organ affected:

  • Lungs: wheezing, cough, shortness of breath, chest pain.
  • Skin: lumps, ulcers, discoloured skin, erythema nodosum.
  • General: fatigue, weight loss, joint aches, arthritis.
Signs and symptoms of sarcoidosis
Signs and symptoms of sarcoidosis
Sarcoid affecting the skin
Sarcoid affecting the skin

Respiratory Tract

Lung involvement is most common, occurring in at least 90% of cases, and can lead to progressive fibrosis. The disease stages in the lungs are classified radiologically:

  1. Bilateral hilar lymphadenopathy (BHL) alone.
  2. BHL with pulmonary infiltrates.
  3. Pulmonary infiltrates without BHL.
  4. Fibrosis.


Cardiac sarcoidosis can cause arrhythmias, heart block, and heart failure. Autopsy studies reveal cardiac involvement in 20-30% of cases in the US and up to 60% in Japan.


Eye involvement includes uveitis and retinal inflammation, potentially leading to loss of vision. Heerfordt syndrome involves anterior uveitis, parotitis, facial nerve paralysis, and fever.

Nervous System

Neurosarcoidosis affects the cranial nerves and can present with facial nerve palsy, optic nerve dysfunction, chronic meningitis, and peripheral neuropathy.

Endocrine and Exocrine

Sarcoidosis can lead to hypercalcaemia due to increased production of 1,25-dihydroxy vitamin D. Thyroid dysfunction and parotid gland enlargement are also observed.

Gastrointestinal and Genitourinary

Though rare, sarcoidosis can affect the gastrointestinal tract and kidneys, mimicking Crohn's disease or leading to nephrocalcinosis.


Common blood anomalies include lymphopenia, anaemia, and monocytosis. Hypergammaglobulinaemia is also frequently observed.

Bone, Joints, and Muscles

Musculoskeletal involvement leads to acute or chronic arthritis, often associated with Löfgren syndrome.


Diagnosis is made through exclusion, involving imaging and biopsy to rule out other conditions like tuberculosis and lymphoma. A chest X-ray or CT scan can reveal lymphadenopathy.

CT scan of the chest showing lymphadenopathy (arrows) in the mediastinum due to sarcoidosis
CT scan of the chest showing lymphadenopathy (arrows) in the mediastinum due to sarcoidosis


Treatment varies greatly, with many requiring no systemic therapy. For symptomatic cases, NSAIDs are first-line treatments. Corticosteroids like prednisone are standard for more severe cases. Steroid-sparing agents such as methotrexate, azathioprine, and mycophenolic acid are used to reduce corticosteroid side effects. Immunosuppressants, like cyclophosphamide and cyclosporine, and biologic agents targeting TNF, such as infliximab, are reserved for refractory cases.

Specific Organ Treatments

Ursodeoxycholic acid is used for liver involvement, and antimalarials like chloroquine are effective for cutaneous sarcoidosis and hypercalcaemia. Thalidomide and phosphodiesterase 4 inhibitors have shown promise in clinical trials for resistant cases.


Prognosis varies; many cases remit spontaneously or with treatment, while others may progress to chronic disease or pulmonary fibrosis. Mortality rates are higher in certain populations, such as African Americans.

Gross pathology image showing sarcoidosis with honeycombing
Gross pathology image showing sarcoidosis with honeycombing


Sarcoidosis affects young adults, with a higher incidence in women and certain ethnic groups, particularly African Americans and Northern Europeans. The disease is less common in South America, India, and Canada.


First described in 1877, sarcoidosis has been known by various names. Significant milestones include the identification of lung involvement in 1915 and the first international sarcoidosis conference in 1958.

Self-assessment MCQs (single best answer)

What is sarcoidosis primarily characterised by?

Which organ is most commonly affected by sarcoidosis?

What is the first radiological stage of lung involvement in sarcoidosis?

What percentage of sarcoidosis cases involve the lungs?

Which syndrome involves anterior uveitis, parotitis, facial nerve paralysis, and fever?

Which blood anomaly is commonly observed in sarcoidosis?

What is the first-line treatment for symptomatic sarcoidosis?

Which immunosuppressant is reserved for refractory cases of sarcoidosis?

Which demographic has a higher incidence of sarcoidosis?

In what year was the first international sarcoidosis conference held?


Dentaljuce provides Enhanced Continuing Professional Development (CPD) with GDC-approved Certificates for dental professionals worldwide.

Founded in 2009 by the award-winning Masters team from the School of Dentistry at the University of Birmingham, Dentaljuce has established itself as the leading platform for online CPD.

With over 100 high-quality online courses available for a single annual membership fee, Dentaljuce offers comprehensive e-learning designed for busy dental professionals.

The courses cover a complete range of topics, from clinical skills to patient communication, and are suitable for dentists, nurses, hygienists, therapists, students, and practice managers.

Dentaljuce features Dr. Aiden, a dentally trained AI-powered personal tutor available 24/7 to assist with queries and provide guidance through complex topics, enhancing the learning experience.

Check out our range of courses, or sign up now!

Membership Options

Dentaljuce offers a range of membership options…

Regular Membership

With enhanced CPD Certificates. Dentaljuce is brought to you by the award winning Masters team from the School of Dentistry, University of Birmingham, UK. All have won awards for web based learning and teaching and are recognised as leaders and innovators in this field, as well as being highly experienced clinical teachers. Full access to over 100 courses, no extras to pay.

Buy Now

£89.00 per year

Student Membership

No Certificates. With universities cutting down on traditional lectures, many students are currently having to rely more on online resources. If you don't need CPD Certificates, we are offering an amazing discount on your Dentaljuce personal membership fee. Special student price just £29 for 12 months individual membership.

Buy Now

£29.00 per year

Very impressed - keep being interrupted by patients turning up!

© Dentaljuce 2024 | Terms & Conditions | Privacy Policy

Recording CPD time: recorded.