Enhanced Verifiable CPD from the
University of Birmingham

Dentaljuce Shorts: 500 words, 10 MCQs, on general medicine and surgery.

Sertoli Cell Tumour

A Sertoli cell tumour is a rare sex cord–gonadal stromal tumour originating from Sertoli cells, which can occur in the testis or ovary. These tumours are most commonly diagnosed in individuals aged 35 to 50. Given their well-differentiated nature, they are sometimes misdiagnosed as seminomas due to their similar appearance.

Micrograph of a Sertoli cell tumour. H&E stain.
Micrograph of a Sertoli cell tumour. H&E stain.


In males, Sertoli cell tumours typically manifest as a testicular mass or firmness. Approximately 25% of cases may present with gynaecomastia if the tumour produces oestrogens. In young boys, these tumours can cause precocious pseudopuberty, particularly if they secrete androgens.


Low magnification micrograph of a Sertoli cell tumour. H&E stain.
Low magnification micrograph of a Sertoli cell tumour. H&E stain.

On ultrasound, a Sertoli cell tumour generally appears as a hypoechoic intratesticular lesion, typically solitary. However, the large cell subtype might present with multiple and bilateral masses featuring extensive calcification. Although MRI can be conducted, it is usually not definitive. A definitive diagnosis is achieved through microscopy and immunohistochemistry, which are very important especially when differentiating from seminomas.


In males, due to the challenges associated with imaging-based identification of these tumours, an orchiectomy is often performed as a diagnostic and therapeutic measure. Given that the majority of Sertoli cell tumours are benign, this surgical intervention is usually sufficient. There is no evidence supporting the efficacy of chemotherapy or radiotherapy in treating Sertoli cell tumours.

In Non-Humans

Sertoli cell tumours are not exclusive to humans; they have been documented in other species such as domestic ducks, dogs, and horses.

Additional Images

Micrograph of a Leydig cell tumour
Micrograph of a Leydig cell tumour.
Micrograph of a Leydig cell tumour
Micrograph of a Leydig cell tumour.

Self-assessment MCQs (single best answer)

What is the typical age range for individuals diagnosed with Sertoli cell tumours?

What symptom might approximately 25% of male patients with Sertoli cell tumours present with?

What imaging technique is typically used to identify a Sertoli cell tumour?

Which of the following is NOT a common presentation of Sertoli cell tumours in males?

Which diagnostic method is definitive for Sertoli cell tumours?

What is the primary treatment for Sertoli cell tumours in males?

Sertoli cell tumours are most commonly misdiagnosed as which other type of tumour?

What percentage of Sertoli cell tumours present with gynaecomastia?

Which of the following is true regarding the efficacy of chemotherapy and radiotherapy in treating Sertoli cell tumours?

Sertoli cell tumours have been documented in which of the following non-human species?


Dentaljuce provides Enhanced Continuing Professional Development (CPD) with GDC-approved Certificates for dental professionals worldwide.

Founded in 2009 by the award-winning Masters team from the School of Dentistry at the University of Birmingham, Dentaljuce has established itself as the leading platform for online CPD.

With over 100 high-quality online courses available for a single annual membership fee, Dentaljuce offers comprehensive e-learning designed for busy dental professionals.

The courses cover a complete range of topics, from clinical skills to patient communication, and are suitable for dentists, nurses, hygienists, therapists, students, and practice managers.

Dentaljuce features Dr. Aiden, a dentally trained AI-powered personal tutor available 24/7 to assist with queries and provide guidance through complex topics, enhancing the learning experience.

Check out our range of courses, or sign up now!

Membership Options

Dentaljuce offers a range of membership options…

Regular Membership

With enhanced CPD Certificates. Dentaljuce is brought to you by the award winning Masters team from the School of Dentistry, University of Birmingham, UK. All have won awards for web based learning and teaching and are recognised as leaders and innovators in this field, as well as being highly experienced clinical teachers. Full access to over 100 courses, no extras to pay.

Buy Now

£89.00 per year

Student Membership

No Certificates. With universities cutting down on traditional lectures, many students are currently having to rely more on online resources. If you don't need CPD Certificates, we are offering an amazing discount on your Dentaljuce personal membership fee. Special student price just £29 for 12 months individual membership.

Buy Now

£29.00 per year

Very good, detail excellent, very clear to use.

© Dentaljuce 2024 | Terms & Conditions | Privacy Policy

Recording CPD time: recorded.